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Semi-crystalline, semi-crystalline, detached phase multi-block copolymers for controlled release of biologically active compounds
Semi-crystalline, semi-crystalline, detached phase multi-block copolymers for controlled release of biologically active compounds
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机译:半结晶,半结晶,分离相多嵌段共聚物,用于生物活性化合物的控制释放
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摘要
This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterised in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions; c) the segments are linked by a multifunctional chain-extender; d) the segments are randomly distributed over the polymer chain; e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.
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