Biofilm developed on the basis of chitosan and healing the hydroalcoholic extract of croton cajucara Benth solubilized in nanoemulsão

摘要

The present invention consists in preparing a formulation for topical use in healing wounds.Developed the basis of biofilm of chitosan combined with nanoemulsion carrier of hydroalcoholic extract obtained from the bark of the stem of croton cajucara Benth (EHA - CC).The main goal of the treatment consists in the quick closure of the lesion, so as to obtain a scar functional and aesthetically satisfactory.Justified by the importance of reducing microbial contamination.Among the methods of treatment of wounds, the patch is used to protect, to absorb exudates and drain the wound, improving the conditions of the wound bed.Assisting in complete healing.In this sense, the biopolymer chitosan (quit) to provide biocompatibility, biodegradability, being non-toxic, possess antimicrobial activities and healing.As well as having the ability to form films resistant and elastic, represents an excellent matrix for the incorporation of drugs for various therapeutic uses.In this invention, EHA - CC extract solution (5 mg to 30 mg) in a system nanoemulsionados (snedds) was biocompatible with the biofilm (quit).From the composition quit / EHA - CC (1: 1) was the formulation quit - CC - snedds (biofilm chitosan containing the extract of EHA - CC incorporated into nanoemulsão type snedds - self - nanoemulsion drug deliveRy system). This set was employed in an experimental in vivo model with the purpose to investigate its potential healing in surgical wounds.The evolution of the healing process in treated animals was evaluated by histopathological studies, which observed the healing efficiency.Induction of neovascularization with satisfactory and formation of collagen fibers, in comparison with the biofilm quit (free of plant).In the present invention claims - if the topical use of biotechnology can quit - DC snedds in surgical wounds, sores, infected wounds, chronic ulcers, diabetic wounds.Burned, among other possibilities.In severe cases, recomenta if topical treatment of biofilm quit - CC - snedds associated with oral administration of nanoemulsão CC - snedds, who in turn.After the evaluation experiments in vivo inflammation and pain, has anti-inflammatory efficacy and anti pain.