Composition for topical use in Photodynamic Therapy (TFD) and Photodiagnosis (FD) and process for preparing the composition

摘要

"Liquid -crystalline phases (lamellate the cubic) as a release system for topical use of photosensitive (photosensitive) compounds from phthalocyanine, porphyrin and chlorine families used in photodynamic therapy (tfd) and for photodiagnosis (fd)". The liquid -crystalline, Lamelar and cubic phases mentioned in that patent are essentially composed of: 95 to 60% by weight, relative to the total weight of the composition, of an unsaturated fatty acid called glyceryl monoleate (monoleine),Containing an 18 -carbon acyl chain, and 5 to 40% by weight of water. At the temperature limit between 20 and 75 198 c, the texture of a liquid crystalline gel presents preferably the cubic phase. The photosensitive compounds (photosensitisers) incorporated in the said lamellar and cubic phases are those belonging to the phthalocyanine, porphyrin and chlorine families in proportion to 0.05 to 2% by weight in relation to the total composition or any other composition not caused by the total composition And no change in the structure of those phases.