Modified Ibuprofen Release Formulation Providing Immediate and Extended Drug Release

摘要

modified release ibuprofen dosage form. The present invention relates to a solid dosage form for oral administration of ibuprofen comprising a modified release formulation of ibuprofen that provides an immediate burst effect and then sustained release of ibuprofen sufficient to maintain blood levels of at least 6. 4 109 g / ml over a prolonged period of at least 8 hours following single dose administration. The dosage form releases ibuprofen at a rate sufficient to initially apply an effective amount of ibuprofen within about 2.0 hours following administration. The dosage form then subsequently applies the remaining amount of ibuprofen at a relatively constant rate sufficient to maintain an ibuprofen level over a predetermined application period for at least 8 hours.