USES OF A THYDILATE SYNTASE INHIBITOR AND ANTICCANE THERAPY

摘要

methods of predicting a cancer patient's response to therapy with 5-fu or another thymidylate synthase inhibitor, To identify a cancer patient and to treat a patient having a pancreatic cancer the present invention provides methods of diagnosing and providing cancer prognosis and therapy including, but not limited to, pancreatic cancer and responsiveness to thymidylate synthase inhibitor therapy (eg, 5-fu), by identifying cancers with altered histone modification patterns selected from the group consisting of h3k4me2, h3k9me2, or h3k18ac.