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Pharmaceutical composition containing sofosbuvir and velpatasvir
Pharmaceutical composition containing sofosbuvir and velpatasvir
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机译:包含索非布韦和维帕他韦的药物组合物
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摘要
The invention relates to a pharmaceutical composition comprising the active ingredients sofosbuvir and velpatasvir, at least one surface stabilizer, wherein all active ingredients are in amorphous forms. Solid pharmaceutical dosage form containing 1-methylethyl - [(S) - {[(2R, 3R, 4R, 5R) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2) -yl) -4 -fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl] methoxy} phenoxyphosphoryl] -1-alaninate also known as sofosbuvir and methyl {(1R) -2 - [(2S, 4S) -2- (5- {2 - [(2S, 5S) -1 - {(2S) -2 - [(methoxycarbonyl) amino] -3-methylbutanoyl} -5-methylpyrrolidin-2-yl] -1,11-dihydro [2] benzopyrano [4 ' , 3 ': 6,7] naphtho [1,2-] imidazol-9-yl} -1-imidazol-2-yl) -4- (methoxymethyl) pyrrolidin-1-yl] -2-oxo-1-phenylethyl } a carbamate also known as velpatasvir and a process for the preparation of this pharmaceutical composition.
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