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HOWEVER, AWESOME ANTI-DISEASE TO HUMANE TSLP RECEPTORS
HOWEVER, AWESOME ANTI-DISEASE TO HUMANE TSLP RECEPTORS
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机译:但是,对于人类TSLP受体而言,真是令人震惊的疾病
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摘要
[Problem] To provide an anti-human TSLP receptor antibody that specifically binds to human TSLP receptor and inhibits an action of human TSLP through human TSLP receptor. [Means for Solution] An anti-human TSLP receptor antibody had been studied by the present inventors, and an anti-human TSLP receptor antibody comprising a heavy chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 118 of SEQ ID NO: 1 and a light chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 108 of SEQ ID NO: 3 was provided. It was revealed that the anti-human TSLP receptor antibody inhibits expression of TARC mRNA induced by TSLP and production of MDC proteins, and suppressed an allergic reaction in a monkey Ascaris antigen sensitization model, and then the present invention was completed.
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机译:[问题]提供与人TSLP受体特异性结合并通过人TSLP受体抑制人TSLP作用的抗人TSLP受体抗体。 [解决方案]本发明人已经研究了抗人TSLP受体抗体,并且该抗人TSLP受体抗体包含重链可变区,该重链可变区由SEQ ID NO:1的氨基酸编号1至118的氨基酸序列组成提供了NO:1和由SEQ ID NO:3的氨基酸编号1至108的氨基酸序列组成的轻链可变区。结果表明,在猴A虫抗原致敏模型中,抗人TSLP受体抗体抑制了由TSLP诱导的TARC mRNA的表达和MDC蛋白的产生,并抑制了过敏反应,从而完成了本发明。
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