polynucleotide, recombinant expression system, vector, polypeptide, recombinant cell, isolated synthetic immune receptor polypeptide or polypeptide heterodimer, immune effector cell or stem cell, immune or effector cell population, methods of manufacturing an immune effector cell that expresses sir, generating an RNA-modified cell population, providing anti-disease immunity and treating or preventing a disease, composition, use or method, kit, and amino acid sequence.

摘要

The disclosure provides synthetic immune receptors (sirs), sirs-encoding nucleic acids, methods of manufacturing and use of sirs in, for example, adoptive cell therapy.