SYSTEM FOR SUSTAINED RELEASE OF HYDROPHOBIC PROTEINS BASED ON A HYALURONIC ACID AMIDE

摘要

The present invention relates to a system for sustained release of biologically active proteins, comprising a) a protein with a hydrophobic nature and b) a hyaluronic acid (HA) amide, wherein the HA used for the preparation of the amide has a weight-average molecular weight ranging between 500 and 730 kDa, wherein said protein with a hydrophobic nature has a GRAVY index not less than -0.5 and the HA amide is selected from HA hexadecylamide: HA amide with hexadecylamine, having a molar amidation percentage ranging between 7 and 14%; HA octylamide: HA amide with octylamine, having a molar amidation percentage ranging between 10 and 15%; HA dodecylamide: HA amide with dodecylamine, having a molar amidation percentage ranging between 10 and 15%; HA tert-butylamide: HA amide with tert-butylamine, having a molar amidation percentage ranging between 7 and 12%; HA benzylamide: HA amide with benzylamine, having a molar amidation percentage ranging between 7 and 15%; and wherein the ratio hyaluronic acid (HA) amide/protein is not less than 10:1. The invention provides sustained, slow release over time which increases the efficacy of the medicament and the patient's compliance.