REDUCTION OF INTENSITY OF SYSTEMIC SCLEROSIS WITH THE HELP OF AGONISTS OF DEATH RECEPTORS

摘要

The present invention relates to methods and compositions for the treatment and / or prevention of autoimmune fibrosis, such as systemic sclerosis (CC, scleroderma). The method includes administering to an individual in need thereof an effective amount of a death receptor agonist. Suitable death receptor agonists include tumor necrosis factor (TNF) associated with an apoptosis inducing ligand (TRAIL), antibodies for the death receptor agonists, and variants, analogs or derivatives thereof. The introduction of a death receptor agonist blocks the activation of fibroblasts or profibrogenic cells and / or reduces or depletes myofibroblasts, thereby reducing or preventing systemic sclerosis.