Nifedipine drug intermediates o-nitrobenzaldehyde synthesis method

摘要

The present invention discloses nifedipine drug intermediates o-nitrobenzaldehyde synthesis method by 3-bromo-2-(1-hydroxyethyl) -nitrobenzene and sodium nitrate solution were added to the reaction vessel, controlled the stirring speed, the solution temperature was reduced, reacted for 60 -80 min, added dichlorobutene solution, added rhodium trichloride in batches; continued to react, the solution was stratified, extracted with chloride dibromomethane solution several times, extracted with the sulfoxide chloride solution several times, washed with potassium nitrate solution several times, separated from the oil layer, dehydrated with agent dehydration, recrystallizated in the 3-chlorotrifluorotoluene solution, got the finished product o-nitrobenzaldehyde. Figure 1