Systems and methods for patient-specific prediction of drug responses from cell line genomics

摘要

Contemplated systems and methods use a priori known cell line genomics and drug-response data to build a library of response predictors across multiple and distinct cell types and drugs. Statistical analysis of selected response predictors using actual patient data is then employed to identify a response predictor that has significant gain in prediction power, and the drug associated with the identified response predictor is then selected for treatment where the response predictor indicated sensitivity to the drug.