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SYSTEMS AND METHODS FOR PATIENT-SPECIFIC PREDICTION OF DRUG RESPONSES FROM CELL LINE GENOMICS
SYSTEMS AND METHODS FOR PATIENT-SPECIFIC PREDICTION OF DRUG RESPONSES FROM CELL LINE GENOMICS
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机译:从细胞系基因组学中患者特异性反应预测的系统和方法
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摘要
To provide systems and methods for building a library of response predictors across multiple and distinct cell types and drugs.SOLUTION: The systems and methods use a priori known cell line genomics and drug-response data. Statistical analysis of selected response predictors using actual patient data is then employed to identify a response predictor that has significant gain in prediction power, and the drug associated with the identified response predictor is then selected for treatment where the response predictor indicated sensitivity to the drug.SELECTED DRAWING: Figure 2A
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