首页> 外国专利> ANTIBACTERIAL BIAROMATIC DERIVATIVES.

ANTIBACTERIAL BIAROMATIC DERIVATIVES.

机译:抗菌双峰衍生物。

摘要

The invention relates to antibacterial compounds of formula I (I) wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (l-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-l-yl or 3,4-dihydroxycyclopentyl)methoxy; U1 is N or CR1, U2 is N or CR2, U3 is N or CR3 and U4 is N or CR4, it being understood that at most three of U1, U2, U3 and U4 can be N at the same time; V1 is N or CR5, V2 is N or CR6, V3 is N or CR7 and V4 is N or CH, it being understood that at most two of V1, V2, V3 and V4 can be N at the same time; R1 is H, cyano, hydroxy or alkoxy; R2 is H, hydroxy or alkoxy; R3 is H, cyano, hydroxy, alkoxy or carboxamido; R4 is H or alkoxy; R5 is H, hydroxy or halogen; R6 is H, hydroxy or halogen; R7 is H; the dotted line "_____ " represents a bond or is absent; W represents CH or N when the dotted line "_____ " is a bond, or W represents CH2 when the dotted line "_____ " is absent; X represents CH or N; and Q represents O or S; and salts thereof.
机译:本发明涉及式I(I)的抗菌化合物,其中R为H,氰基,烷氧基,氰基甲氧基,环烷基甲氧基,羟基烷氧基,烷氧基烷氧基,烷氧基羰基,2-乙氧基-2-氧乙氧基,2-(甲基氨基)-2-氧乙氧基,( 1-氰基环丁基)甲氧基,3-羟基-吡咯烷-1-基或3,4-二羟基环戊基)甲氧基; U1为N或CR1,U2为N或CR2,U3为N或CR3,U4为N或CR4,可以理解的是,U1,U2,U3和U4中最多三个可以同时为N。 V1为N或CR5,V2为N或CR6,V3为N或CR7,V4为N或CH,可以理解的是,V1,V2,V3和V4中的至多两个可以同时为N。 R1是H,氰基,羟基或烷氧基; R 2是H,羟基或烷氧基; R3是H,氰基,羟基,烷氧基或羧酰胺基; R4是H或烷氧基; R5是H,羟基或卤素; R6是H,羟基或卤素; R7为H;虚线“ _____”表示键或不存在;当虚线“ _____”为键时,W表示CH或N;当虚线“ _____”不存在时,W表示CH2; X代表CH或N; Q表示O或S;及其盐。

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