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NMDA Spiro-Lactam and BIS-Spiro-Lactam Receiver Modulators and Their Application

机译:NMDA Spiro-Lactam和BIS-Spiro-Lactam接收器调制器及其应用

摘要

It refers to a compound represented by Formula I or Formula II; or a pharmacologically acceptable salt, a stereoisomer and/or a positive oxidant, characterized by the fact that R1 and R2 are selected independently of H, C1-C6 and other substances; and R3 is selected from H, C1-C6 tars. In addition, R4, R5, R6 and R7 are independent of H, halogen, hydroxyl, etc. as well as a pharmacological formulation or synthesis, including the invention of a compound (possibly its various racemic or stereoisomerization mixtures) and a pharmacist who accepts B in pre-pharmacology. The forum where you want to post is a He also mentioned methods of preparation and treatment.For this purpose, a combination therapy of one or more other active agents can also be used. Current inventions help to treat depression and related diseases by regulating the activity of N-met-D-Asparato (NMDA) receivers.
机译:它是指由式I或式II表示的化合物;或药理学上可接受的盐,立体异构体和/或正氧化剂,其特征在于R1和R2的选择独立于H,C1-C6和其他物质; R3选自H,C1-C6焦油。另外,R 4,R 5,R 6和R 7不依赖于H,卤素,羟基等,以及药理制剂或合成,包括化合物的发明(可能是其各种外消旋或立体异构化混合物)和接受B在药理学前。他还提到了制备和治疗方法。为此,还可以使用一种或多种其他活性剂的联合疗法。当前的发明通过调节N-met-D-天冬酰胺(NMDA)受体的活性来帮助治疗抑郁症和相关疾病。

著录项

  • 公开/公告号PE20190502A1

    专利类型

  • 公开/公告日2019-04-10

    原文格式PDF

  • 申请/专利权人 APTINYX INC.;

    申请/专利号PE2019000295

  • 发明设计人 KHAN M. AMIN;

    申请日2017-08-01

  • 分类号C07D487/20;A61K31/4747;A61P25;

  • 国家 PE

  • 入库时间 2022-08-21 12:01:23

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