RNA aptamers that inhibit proteolytic activity of mouse's metalloproteases ADAM10 and/or ADAM17, complex, pharmaceutical composition, diagnostic reagent and application of the aptamers

摘要

The application is for a pharmacy affiliated to ADAM1O protein and /or ADAM17 protein,containing the nucleotide sequence selected from SEQ ID NO 1 and /or SEQ ID NO 4 and /or SEQ ID NO 5,their fragments or regions of variation,a rolling or non -rolling complex containing an aptamer as declared and a functional substance,pharmaceutical composition,containing an aptamer or complexion and a diagnostic reagent for the determination of ADAM10 or ADAM17 protein concentration,Detection reagent to detect the presence of ADAM10 protein and /or ADAM17 protein or a marker reagent for ADAM10 protein and /or ADAM17 protein containing an aptamer or a covalent or non -covalent complex,and the use of an aptamer to inhibit the activity of ADAM10 and /or ADAM17 protein. Another subject of the application is also the use of the pharmacy,a complex or pharmaceutical composition for the manufacture of a medicinal product for the treatment of a disease mediated by ADAM10 and /or ADAM17 protein and for the determination of the concentration of ADAM10 and /or ADAM17 protein in vitro and in vivo,or to detect the presence of ADAM10 and /or ADAM17 protein in vitro and in vivo or to label ADAM10 and /or ADAM17 protein in vitro and in vivo.