首页>
外国专利>
Lentiviral vectors, THERE IS PSEUDO TYPE PARTICULAR WITH an envelope glycoprotein of Sindbis virus
Lentiviral vectors, THERE IS PSEUDO TYPE PARTICULAR WITH an envelope glycoprotein of Sindbis virus
展开▼
机译:慢病毒载体,其中有伪型,带有信德比斯病毒的包膜糖蛋白
展开▼
页面导航
摘要
著录项
相似文献
摘要
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).
展开▼