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MUTANT SPIKE PROTEIN EXTENDING THE TISSUE TROPISM OF INFECTIOUS BRONCHITIS VIRUS (IBV)
MUTANT SPIKE PROTEIN EXTENDING THE TISSUE TROPISM OF INFECTIOUS BRONCHITIS VIRUS (IBV)
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机译:扩展了支气管炎病毒(IBV)组织恐怖性的突变体突突蛋白
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摘要
The present invention provides an infectious bronchitis virus (IBV) spike protein (S protein) which is based on an S protein from an IBV strain with restricted tissue tropism, but which comprises the sequence XBBXBX in the part of the S2 protein corresponding to residues 686 to 691 of the sequence given as SEQ ID No. 2, where B is a basic residue and X is any amino acid; and which comprises at least one of the following amino acid substitutions with reference to the position numbering of SEQ ID NO:2: Leucine (L) to Phenylalanine (F) at position 578 Asparagine (N) to Serine (S) at position 617 Asparagine (N) to Serine (S) at position 826 Leucine (L) to Phenylalanine (F) at position 857 and Isoleucine (I) to Valine (V) at position 1000 such that an IBV virus comprising the S protein has extended tissue tropism. The present invention also provides a virus comprising such an S protein.
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机译:本发明提供了一种传染性支气管炎病毒(IBV)刺突蛋白(S蛋白),其基于来自具有组织定向受限的IBV毒株的S蛋白,但是在S2蛋白的一部分中包含对应于残基686的序列XBBXBX。 -SEQ ID No.2给出的序列的691至其中691,其中B是碱性残基,X是任何氨基酸;且其包含至少一个以下氨基酸取代,所述氨基酸取代涉及SEQ ID NO:2的位置编号:578位天冬酰胺(N)的亮氨酸(L)到617位天冬酰胺的丝氨酸(S)的苯丙氨酸(F) (N)到826位的丝氨酸(S)到857位的亮氨酸(L)到苯丙氨酸(F)以及1000位的异亮氨酸(I)到缬氨酸(V),使得包含S蛋白的IBV病毒具有扩展的组织嗜性。本发明还提供了包含这种S蛋白的病毒。
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