Methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders and associated processes

摘要

A method of measuring alpha-synuclein level in vitro comprising: contacting a biological sample from a subject with a detectable isotope; measure the level of labeled alpha-synuclein in a sample; and comparing the level of labeled alpha-synuclein in the sample with a corresponding normal sample; where a change in the alpha synuclein level of the sample compared to the corresponding normal sample is determined to predict neurological or neurodegenerative disease, and / or identify the efficacy of a therapeutic regimen; and where the neurological or neurodegenerative disease is Parkinson's disease.