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Analysis based on the size of fetal DNA in maternal plasma
Analysis based on the size of fetal DNA in maternal plasma
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机译:基于母体血浆中胎儿DNA大小的分析
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摘要
A method of analyzing a biological sample of an organism, the biological sample including DNA originating from normal cells and potentially from cells associated with cancer, wherein at least some of the DNA is cell-free in the biological sample, the method comprising: for each size of a plurality of sizes: measuring an amount of a first set of DNA fragments from the biological sample corresponding to the size; calculating a first value of a first parameter based on the amounts of DNA fragments at multiple sizes, the first parameter providing a statistical measure of a size profile of DNA fragments in the biological sample; comparing the first value to a reference value; and determining a classification of a level of cancer in the organism based on the comparison.
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