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COMBINATION THERAPY USING RIBAVIRIN AS EIF4E INHIBITOR
COMBINATION THERAPY USING RIBAVIRIN AS EIF4E INHIBITOR
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机译:利巴韦林作为EIF4E抑制剂的联合治疗
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摘要
The present invention relates to pharmaceutical compositions and combination therapies for treating patents having a neoplasm or proliferative disorder, the combination comprises an inhibitor of the elF4E gene product and a chemotherapeutic agent, wherein said combination therapy overcomes resistance developed in patients during anti-neoplastic treatment. The present invention also provides for the use of a combination therapy for treating patients having a neoplasm, a proliferative disorder, pre-neoplasm or a precancerous lesion, comprising an inhibitor of the elF4E gene product, a chemotherapeutic agent, and a therapeutically effective amount of a hedgehog pathway inhibitor, and the method of using said combination therapy.
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