TOPICAL OINTMENT FORMULATIONS OF PDE-4 INHIBITOR AND THEIR USE IN TREATING SKIN CONDITIONS

摘要

Embodiments herein are directed to topical compositions comprising a therapeutically effective amount of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid, PEG 400, PEG 4000, white petrolatum, vitamin E, glycerol monostearate/glycerides, isopropyl myristate, and water. The topical compositions may be used to treat a variety of skin conditions, including atopic dermatitis. Patients treated include pediatrics, adolescents and adults.