Topical ointment formulations of PDE-4 inhibitors and their use in the treatment of skin conditions

摘要

An embodiment of the present invention is a therapeutically effective amount of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid, PEG 400, PEG 4000, white petrolatum, vitamin E, glycerol monostearate/glyceride, isopropyl myristate, and a topical composition comprising water. Topical compositions can be used to treat a variety of skin conditions, including atopic dermatitis. Patients to be treated include children, adolescents and adults.