HUMAN NOSE INFERIOR NASAL CONCHA-DERIVED MESENCHYMAL STEM CELL-BASED, 3D BIOPRINTED CONSTRUCT, AND USE THEREOF

摘要

The present invention relates to a method for fabricating a human nose inferior nasal concha-derived mesenchymal stem cell-based, 3D bioprinted construct, and a use thereof. Conventional mesenchymal stem cells are accompanied by a severe pain in the acquirement procedure thereof, have a limitation to the time of acquirement, and require much time and cost and have a high risk of being contaminated during the cultivation thereof in a sufficient quantity. In contrast, human nose inferior nasal concha-derived mesenchymal stem cells have the advantage of being at a low risk of operation for the acquirement thereof and being able to be acquired in a sufficient amount anytime. In addition, a human nose inferior nasal concha-derived mesenchymal stem cell-based, 3D bioprinted construct is advantageous over conventional mesenchymal stem cell-based, 3D bioprinted constructs in that the former can survive and proliferate stably in vitro and/or in vivo and shows high osteogenic differentiation as well. Thanks to the advantages, human nose inferior nasal concha-derived mesenchymal stem cells allow the easy fabrication of 3D bioprinted constructs which are thus expected to make a great contribution to the practical use of cell therapy products.