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ANTAGONISTS OF CAV2.3 R-TYPE CALCIUM CHANNELS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

机译：CAV2.3 R型钙离子通道治疗神经退行性疾病的拮抗剂

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摘要

The invention provides Cav2.3 R-type voltage gated calcium channel (coded by the CACNA1E gene) antagonists for the treatment and for use in the treatment of neurodegenerative diseases, in particular Parkinson's disease, and pharmaceutical compositions comprising these Cav2.3 R-type calcium channel antagonists. The invention further provide methods for identifying an antagonist of a Cav2.3 R-type calcium channel and testing a compound for activity as an antagonist of a Cav2.3 R-type calcium channel.

机译：本发明提供了用于治疗和用于治疗神经退行性疾病，特别是帕金森氏病的Cav2.3 R型电压门控钙通道（由 CACNA1E基因编码）拮抗剂，以及包含这些Cav2.3 R型钙通道拮抗剂。本发明进一步提供了鉴定Cav2.3 R型钙通道拮抗剂的方法，并测试化合物作为Cav2.3 R型钙通道拮抗剂的活性。 展开▼

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公开/公告号WO2018229230A1

专利类型

公开/公告日2018-12-20

原文格式PDF

申请/专利权人 UNIVERSITÄT ULM;LISS BIRGIT;
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申请/专利号WO2018EP65893

发明设计人 LISS BIRGIT;
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申请日2018-06-14

分类号A61K38/16;A61K45/06;A61P25/28;A61K31/137;

国家 WO

入库时间 2022-08-21 11:57:42

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3. ANTAGONISTS OF CAV2.3 R-TYPE CALCIUM CHANNELS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES [P] . 欧洲知识产权局专利： EP3638285A1 . 2020-04-22

机译： CAV2.3 R型钙离子通道治疗神经退行性疾病的拮抗剂

4. ANTAGONISTS OF CAV2.3 R-TYPE CALCIUM CHANNELS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES [P] . 欧洲知识产权局专利： EP3638283A1 . 2020-04-22

机译： CAV2.3 R型钙离子通道治疗神经退行性疾病的拮抗剂

5. ANTAGONISTS OF CAV2.3 R-TYPE CALCIUM CHANNELS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES [P] . 世界知识产权组织专利： WO2018228692A1 . 2018-12-20

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4. Neuroimmune connections between corticotropin- releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases [J] . Piplu Bhuiyan, Yi-Wei Wang, Huan-Huan Sha, 中国神经再生研究（英文版） . 2021,第011期

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6. Cav2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo (Retraction of vol 54, pg 1542, 2013) [J] . Dibue M., Kamp M. A., Alpdogan S., Epilepsia: Journal of the International League against Epilepsy . 2016,第11期

7. In response: Cav2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo [J] . Dibue-Adjei Maxine, Schneider Toni Epilepsia: Journal of the International League against Epilepsy . 2015,第7期

8. Reactive near field electromagnetic axonal communication channels and their role in neurodegenerative diseases [C] . Morgera Salvatore Domenic Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

9. Mechanisms of R-type calcium channel regulation in the enteric nervous system [D] . Naidoo, Vinogran 2009

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11. Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo [O] . Maxine Dibué-Adjei, Marcel A. Kamp, Serdar Alpdogan, 2017

1. The combination of disease and Zheng (syndrome) on the basic of differentiation of six channels:a new pattern of disease diagnosis and treatment of traditional Chinese medicine [J] . Xue Yang1 ,Xiong-Zhi Wu1 . 传统医学研究（TMR） . 2017,第002期

2. 老年神经退行性疾病与神经精神疾病-治疗与机制研究国际进展论坛主席 [C] . Hanting Zhang . 2016'国际老年健康论坛·泰山 . 2016

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