A plague prevention pill, preparation method thereof. The pill is prepared by mixing a main medicine agent and a secondary medicine agent. The main medicine agent is prepared with the following ingredients: Radix et Rhizoma Rhei from Sichuan province, Radix Scrophulariae, Perillae Herba, Radix Puerariae, Radix Bupleuri, Herba Elsholtziae, Herba Pogostemonis, Fructus Aurantii, Radix Trichosanthis, Radix Paeoniae Rubra, Fructus Forsythiae, Rhizoma seu Radix Notopterygii, Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Schizonepetae, Radix Scutellariae, Radix Clematidis, and Herba Asari. The secondary medicine agent is prepared with the following ingredients: juice of Artemisiae Apiaceae, and old rice.
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