NOVEL FORMULATIONS USEFUL IN TREATING FOLATE DEFICIENCIES

摘要

Provided herein are novel extended release formulations of L-methylfolate ("5- methyltetrahydrofolate" or "5-MTHF"). The extended release compositions and formulations provided herein may be used to treat a variety of disorders associated with folate deficiencies, including central nervous system (CNS) disorders such as, seizures, ataxia, neuropathy, developmental delay, cognitive dysfunction (as in dementia) and psychiatric disorders as well as cerebral folate deficiency (CFD). Also provided herein are methods of diagnosing and/or treating a disease or disorder in a subject by administering extended release compositions or formulations comprising 5-MTHF.