Control of Alcoholism-Related Folate Deficiency by Regulation of Urinary Folate Excretion.

摘要

Health-related consequences of heavy drinking include nutritional deficiencies. Folate deficiency occurs from multiple causes including increased urinary folate excretion. Ethanol decreases the renal reabsorption of folate leading to increased excretion The main aim of this research is to determine the mechanism by which ethanol decreases folate transport by the kidney. Initially the effects of ethanol on expression of the two renal transport proteins the folate receptor (FR) and the reduced folate carrier (RFc) were determined in vivo and in vitro.