EGFR SINGLE-DOMAIN ANTIBODY CART FOR TREATING TUMOR AND APPLICATION THEREOF

摘要

Provided is a CART cell modified by an EGFR single-domain antibody, wherein the CART cell can be used to treat a tumor. Also provided are a humanized EGFR single-domain antibody gene and a single-domain antibody encoded thereby, an EGFR CAR gene and an EGFR CAR chimeric antigen receptor encoded thereby, and a lentiviral vector Pre-Lenti-EF1-EGFR CAR containing the EGFR CAR gene.