首页> 外国专利> Targeting O-acetylated GD2 ganglioside as a new therapeutic and diagnostic strategy for Cancer Stem Cells Cancer

Targeting O-acetylated GD2 ganglioside as a new therapeutic and diagnostic strategy for Cancer Stem Cells Cancer

机译：靶向O-乙酰化GD2神经节苷脂作为癌症干细胞癌的新治疗和诊断策略

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摘要

The present disclosure relates to an antibody recognizing the O-acetylated-GD2 ganglioside for the treatment of Cancer Stem Cells (CSC) cancer. The present disclosure further concern a pharmaceutical composition comprising said antibody for treating a CSC cancer and a method for treating a CSC cancer in a patient in need thereof, said method comprising administering said antibody to said patient. The present disclosure also relates to a method for diagnosing a CSC and to the use of the 0-acetylated-GD2 ganglioside as a biomarker of CSC cancer. Finally, the disclosure relates to a method for predicting the response of a subject affected with CSC cancer to a treatment with an antibody or a composition of the invention.

机译：本公开涉及识别O-乙酰化GD2神经节苷脂用于治疗癌症干细胞（CSC）癌症的抗体。本公开进一步涉及包含所述用于治疗CSC癌症的抗体的药物组合物和用于在有此需要的患者中治疗CSC癌症的方法，所述方法包括向所述患者施用所述抗体。本公开还涉及用于诊断CSC的方法，并且涉及0-乙酰化的GD2神经节苷脂作为CSC癌症的生物标记物的用途。最后，本公开涉及一种预测受CSC癌症影响的受试者对用本发明的抗体或组合物治疗的反应的方法。

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公开/公告号AU2014261788B2

专利类型
公开/公告日2019-07-11

原文格式PDF
申请/专利权人 UNIVERSITE DE NANTES;OGD2 PHARMA;
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申请/专利号AU20140261788
发明设计人 BIRKLE STEPHANE;COCHONNEAU DENIS;DORVILLIUS MYLENE;LE DOUSSAL JEAN-MARC;TERME MICKAEL;
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申请日2014-04-29
分类号C07K16/30;
国家 AU
入库时间 2022-08-21 11:57:09

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