Targeting Midbodies in Ovarian Cancer Stem Cells as a Therapeutic Strategy.

摘要

The etiology, development and progression of ovarian tumorigenesis are among the least understood of all human malignancies. A major difficulty in the treatment of ovarian cancer is tumor recurrence and chemoresistance. One explanation for these impediments to a cure is that a subset of cancer cells, cancer stem cells , is both the source of ovarian cancer and a major contributor to the refractory nature of ovarian cancer to chemotherapeutic challenge. A better understanding of ovarian cancer stem cells and their contribution to ovarian cancer is essential and may be the best strategy to ameliorate the disease. The cancer stem cell theory has been embraced as an attractive hypothesis for generating and propagating human tumors. Putative ovarian cancer stem cells have been identified in human and used to induce tumors and serial tumor propagation in mice. However, there has been limited success in therapeutic targeting of CSCs for ovarian tumor eradication.