Method for detecting dissolution rate of preparation containing colloidal bismuth pectin

摘要

A method for detecting the dissolution rate of a preparation containing colloidal bismuth pectin, according to the dissolution rate measurement in Appendix C, Part II, Chinese Pharmacopoeia 2010. The method comprises dissolving the preparation containing colloidal bismuth pectin in a dissolution medium, then directly taking the dissolved solution, adding a proton acid dissociation agent until the hydrogen ion concentration in the dissolved solution is 0.8-1.2 mol/L, separating the supernatant by centrifugation, adding a colour development solution of citric acid or ascorbic acid and potassium iodide for colour development, and measuring and calculating the dissolved amount of colloidal bismuth pectin in terms of bismuth by a spectrophotometric method. By the method for determining the dissolution rate of a colloidal bismuth pectin preparation established in the present invention, the dissolution curve and the dissolution rate of colloidal bismuth pectin in a preparation containing colloidal bismuth pectin can be determined well, meeting the requirements on quality control.