Transcatheter heart valve replacement systems, heart valve prostheses, and methods for percutaneous heart valve replacement

摘要

Prosthetic heart valve devices, heart valve replacement systems and associated methods for percutaneous heart valve replacement are disclosed herein. A transcatheter heart valve prosthesis (100) configured in accordance herewith includes an expandable frame (110) having a plurality of commissure posts (130) extending therefrom, a radially expandable inflow member (140) attached to the plurality of commissure posts, and a locking mechanism (170) operably coupled to a wire (160). The wire is at least partially slideably disposed within a channel (146) formed in a wall of the inflow member and the locking mechanism is configured to permit the wire to be advanced within the channel to thereby transition the inflow member into a deployed configuration that at least partially engages tissue at the native heart valve.