USE OF miR-18b FOR PREVENTION, TREATMENT, OR DIAGNOSIS OF MUSCLE DISEASE AND NEUROMUSCULAR DISEASE

摘要

The present invention relates to a use of miR-18b for prevention, treatment, or diagnosis of muscular disease or neuromuscular disease. More particularly, it was observed in a gene mutation-induced muscular disease model that gene mutation downregulates the expression of miR-18b to cause an impairment in controlling the miR-18b signaling pathway, thereby suppressing calcium signaling and cell differentiation and inducing apoptosis. Therefore, miR-18b according to the present invention can be utilized as a target factor for diagnosis and treatment of muscular diseases caused by gene mutation, such as ALS and DMD.