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Identification of drugs targeting non-genetic drug tolerance programs in cancer
Identification of drugs targeting non-genetic drug tolerance programs in cancer
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机译:鉴定针对癌症非遗传药物耐受性计划的药物
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摘要
A cell-based screening method is provided. The screening method aims to identify drugs for the treatment of cancers characterized by cells with an over-activated signalling pathway in a combination medicament with an inhibitor of the respective over-activated signalling pathway. In particular, the expression level of SOX2 is determined to identify compounds that prevent the development of resistance to inhibitors of the MAPK and EGFR pathway.
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