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IDENTIFICATION OF DRUGS TARGETING NON-GENETIC DRUG TOLERANCE PROGRAMS IN CANCER

机译：靶向癌症的非遗传药物耐受性计划的药物鉴定

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摘要

A cell-based screening method is provided. The screening method aims to identify drugs for the treatment of cancers characterized by cells with an over-activated signalling pathway in a combination medicament with an inhibitor of the respective over-activated signalling pathway. In particular, the expression level of SOX2 is determined to identify compounds that prevent the development of resistance to inhibitors of the MAPK and EGFR pathway.

机译：提供了一种基于细胞的筛选方法。筛选方法旨在鉴定用于治疗癌症的药物，其特征在于在与相应的过度活化的信号途径的抑制剂的组合药物中具有过度活化的信号途径的细胞。具体而言，确定SOX 2 的表达水平以鉴定阻止对MAPK和EGFR通路抑制剂产生抗性的化合物。 展开▼

著录项

公开/公告号US2020087732A1

专利类型

公开/公告日2020-03-19

原文格式PDF

申请/专利权人 ETH ZURICH;
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申请/专利号US201716471881

发明设计人 WILHELM KREK;STEFANIE FLUCKIGER-MANGUAL;
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申请日2017-12-20

分类号C12Q1/6886;

国家 US

入库时间 2022-08-21 11:23:43

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