Identification of Drugs Targeting Non-genetic Drug Tolerance Programs in Cancer

摘要

Cell-based screening methods are provided. The screening method aims to identify a drug for treating cancer characterized by a cell having an over-activated signaling pathway in a medicament in combination with an inhibitor of an individual over-activated signaling pathway. Specifically, the expression level of SOX2 is determined to identify compounds that prevent the development of resistance to inhibitors of the MAPK and EGFR pathways.