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Human-enzyme mediated depletion of homocysteine for treating patients with hyperhomocysteinemia and homocystinuria
Human-enzyme mediated depletion of homocysteine for treating patients with hyperhomocysteinemia and homocystinuria
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机译:人类酶介导的高半胱氨酸消耗治疗高同型半胱氨酸血症和高半胱氨酸尿症的患者
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摘要
Methods and compositions relating to the engineering of an improved protein with homocyst(e)inase enzyme activity are described. For example, there are disclosed modified cystathionine-Y-lyase (CGL) enzymes comprising one or more amino acid substitutions and capable of degrading homocysteine. Furthermore, provided are compositions and methods for the treatment of homocystinuria or hyperhomocysteinemia with homocysteine depletion using the disclosed enzymes or nucleic acids.
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