MECHANISM OF ACTION DERIVATION FOR DRUG CANDIDATE ADVERSE DRUG REACTION PREDICTIONS

摘要

Embodiments include methods, systems, and computer program products for generating a mechanism of action hypothesis. Aspects include receiving a drug candidate data along with.a plurality of predicted adverse drug reactions (ADRs) associated: with the drug candidate data. Aspects include. receiving a drug pathway data for the drug candidate and adverse drug reaction pathway data for each of the plurality of predicted adverse drug reactions. Aspects include building a pathway network, whereirs the pathway network includes a plurality of drug pathway nodes, a plurality of ADR pathway nodes, and a plurality of pathway connections. Aspects also include generating a pathway output.