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GLUCOSE TRANSPORTER INHIBITOR-MODIFIED INSULIN FOR GLUCOSE-RESPONSIVE INSULIN DELIVERY
GLUCOSE TRANSPORTER INHIBITOR-MODIFIED INSULIN FOR GLUCOSE-RESPONSIVE INSULIN DELIVERY
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机译:葡萄糖转运蛋白抑制剂修饰的胰岛素,用于葡萄糖敏感的胰岛素输送
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摘要
Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with a competitive inhibitor of a glucose transporter, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo.
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