Hypoxia and H_2O_2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

摘要

Conclusions: An effective glucose-responsive insulin delivery strategy based on hypoxia and H_2O_2 dual-sensitive vesicles was developed for diabetes treatment without long-term side effect. Additionally, this dual-sensitive formulation strategy displays the potential benefit in controlled delivery for other therapeutic agents under hypoxia and high oxidative stress.