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PATCH LOADED WITH DUAL-SENSITIVE VESICLES FOR ENHANCED GLUCOSE-RESPONSIVE INSULIN DELIVERY
PATCH LOADED WITH DUAL-SENSITIVE VESICLES FOR ENHANCED GLUCOSE-RESPONSIVE INSULIN DELIVERY
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机译:装有双敏感囊的贴片可增强葡萄糖反应性胰岛素的输送
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摘要
A composition comprising an amphiphilic polymeric material that is both hydrogen peroxide- and hypoxia-sensitive is described. The composition can further include a glucose-oxidizing enzyme and insulin, a bioactive derivative thereof, and/or another therapeutic agent (e.g., another diabetes treatment agent). The polymeric material can form vesicles that comprise single or multiple layers of the polymeric material that enclose the glucose-oxidizing enzyme and the insulin, bioactive derivative and/or other therapeutic agent. The vesicles can be loaded into microneedles to, for example, prepare microneedle arrays for skin patches. Methods of delivering insulin to a subject using the compositions, vesicles, microneedles, and/or microneedle array skin patches are also described.
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