The present invention relates to a method for treating liver cancer using hepatic artery administration of an oncolytic virus. The method for treating liver cancer using hepatic artery administration of an oncolytic virus according to the present invention optimizes hepatic artery administration conditions and thus is safe, and can maximize an anticancer effect by delivering a larger amount of an oncolytic virus to a tumor while minimizing the exposure of the oncolytic virus. Therefore, the method can be effectively used to treat liver cancer.
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