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COMPOSITIONS AND METHODS FOR ABLATING NICHE CELLS IN TESTIS AND OTHER EPITHELIAL CELLS AND METHODS RELATING THERETO
COMPOSITIONS AND METHODS FOR ABLATING NICHE CELLS IN TESTIS AND OTHER EPITHELIAL CELLS AND METHODS RELATING THERETO
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机译:消融睾丸及其他上皮细胞中壁NI细胞的组合物和方法及其相关方法
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摘要
The present disclosure relates to compositions and methods for ablating epithelial cells, in particular to methods for ablating Sertoli cells in testis, and methods related thereto. In particular, the present disclosure relates to methods for ablating Sertoli and other cells in the testis using benzalkonium chloride, to methods for rescuing endogenous spermatogenesis in a subject suffering from Sertoli cell dysfunction, to methods of reconstructing spermatogenesis, to methods of treating infertility, and to methods for the selective depletion of epithelial cells in a tissue and for the treatment of diseases or disorders associated with damaged epithelial cells.
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