METHOD FOR ADJUSTING EFFECTIVE SIZE OF SOLID-STATE NANOPORE IN SOLID-STATE NANOPORE SYSTEM

摘要

A method for adjusting an effective size of a solid-state nanopore (1) in a solid-state nanopore system. The solid-state nanopore system comprises an electrolyte solution (4), a semiconductor substrate (3), and a voltage assembly (5). The semiconductor substrate (3) is provided with the solid-state nanopores (1), and is disposed in the electrolyte solution (4), icons are adsorbed to wall surfaces of the solid-state nanopores (1) to form a double electric layer (2), and the voltage assembly (5) is electrically connected to the semiconductor substrate (3). The method comprises: applying preset voltages of different voltage values on a semiconductor substrate (3) by means of a voltage assembly (5), so as to obtain effective sizes of solid-state nanopores (1) of different sizes. The method can be reversible, has a high efficiency and low costs, produces no harm, does not affect surface features of the solid-state nanopores (1) due to introduction of a foreign material, and does not have a negative effect on the lengths of the solid-state nanopores (1) and the like, and the form retention of the solid-state nanopores (1) is good; and the method has simple operation steps, saves time and labor and has good controllability, and the adjustment can be automatically implemented in real time.