SACUBITRIL SODIUM SALT, EUTECTIC OF SACUBITRIL FREE ACID AND ACETIC ACID, CRYSTAL FORM THEREOF, METHOD FOR PREPARING CRYSTAL FORM, AND USE THEREOF

摘要

The present invention relates to a sacubitril sodium salt as represented by formula IV, a eutectic of sacubitril free acid and acetic acid, a crystal form of the eutectic and a preparation method for the crystal form, and a method for using the eutectic having the described crystal form to prepare LCZ696. The eutectic provided by the present invention may form a stable crystal form and does not easily absorb moisture; the eutectic has good thermal stability, facilitates the purification of sacubitril, is good for storage, and is helpful in synthesizing LCZ696. Moreover, the eutectic provided by the present invention may be directly used for preparing LCZ696 without additional ion exchange, thus being helpful in controlling the type and content of counter cations.