ENDOTRACHEAL TUBE LOADED WITH ANTIMICROBIAL PEPTIDE MDC COATING AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

摘要

An endotracheal tube loaded with antimicrobial peptide MDC coating and a preparation method therefor and an application thereof. The endotracheal tube uses antimicrobial peptide MDC as the antibacterial agent and uses chitosan gel as the fixing and slow-release substrate to perform surface coating on the endotracheal tube to make an endotracheal tube loaded with antimicrobial peptide MDC coating. The antimicrobial peptide MDC sequence is shown as SEQ ID NO:1. The endotracheal tube loaded with antimicrobial peptide MDC coating has significant antibiotic properties and can effectively prevent colonization and growth of the bacteria. Therefore, when the endotracheal tube loaded with antimicrobial peptide MDC coating is applies to artificial tracheal intubation and ventilator, the occurrence of tracheal intubation ventilator-associated pneumonia can be decreased or delayed, the medical economic burden can be reduced, and the patient's physical and mental pain can be relieved. Thus, the prospect is vast.