COMPOSITION FOR PREVENTING, IMPROVING OR TREATING DEGENERATIVE NEUROLOGICAL DISEASE COMPRISING FRACTION OF AQUILARIA AGALLOCHAROXBURGH EXTRACT AS ACTIVE INGREDIENT

摘要

The present invention relates to a composition for preventing, improving or treating degenerative neurological diseases comprising a fraction of Aquilaria agallocha Roxburgh extract as an active ingredient. The composition comprising a fraction of Aquilaria agallocha Roxburgh extract as an active ingredient according to the present invention exhibits antioxidant activity, inhibition of apoptosis of neuronal cells, inhibition of cranial nerve stress, neuronal cell protection, inhibition of the production of reactive oxygen species (ROS) in neuronal cells, decrease in phosphorylation level of extracellular signal-regulated kinases (ERK), inhibition of the production of nitric oxide (NO) in neuronal cells, and inhibition of DNA segmentation of neuronal cells. Accordingly, the composition has an effect on degenerative neurological diseases, such as Alzheimer's disease, Parkinson's disease, Lou Gehrig disease, Huntington's disease, multiple sclerosis, stroke, thrombosis, embolism, head trauma, metabolic disorder of cerebral circulation, brain functional coma or dementia, etc.