METHOD FOR DIAGNOSING IRRITABLE BOWEL SYNDROME VIA BACTERIAL METAGENOMIC ANALYSIS

摘要

The present invention relates to a method for diagnosing irritable bowel syndrome via bacterial metagenomic analysis and, more particularly, to a method for diagnosing irritable bowel syndrome by performing bacterial metagenomic analysis using a subject-derived sample and thereby analyzing an increase or decrease in the amount of extracellular vesicles derived from a particular bacterium. Extracellular vesicles secreted from bacteria present in the bowel are absorbed into the body and may have a direct impact on inflammation production and bowel functions, and irritable bowel syndrome is difficult to diagnose early before any symptoms appear, which makes efficient treatment thereof difficult. Thus, via the metagenomic analysis of bacteria-derived extracellular vesicles using a human body-derived sample according to the present invention, the risk of the onset of irritable bowel syndrome can be predicted in advance, allowing a group at risk of the irritable bowel syndrome to be early diagnosed and predicted and delaying the time of the onset or preventing the onset through appropriate care, and a causative agent can be diagnosed even after the onset, increasing the therapeutic effect of the irritable bowel syndrome with a food or drug for controlling the causative agent.