ISCHEMIC-LESION-SITE-SPECIFIC GENE THERAPY

摘要

In one embodiment, the present invention provides an antisense nucleic acid drug capable of modulating the expression of a target transcript at an ischemic site of a subject. In one embodiment, the present invention provides a composition for modulating the expression of a target transcript at an ischemic site of a subject, the composition including a nucleic acid complex obtained by annealing to each other a first nucleic acid strand that includes an antisense oligonucleotide region for a target transcript and a second nucleic acid strand that includes a complementary region complementary to at least part of the first nucleic acid strand, a lipid being bound to the second nucleic acid strand.